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Proc Natl Acad Sci U S A February 16, 1999; 96 (4): 1469-74.

Organization of an echinoderm Hox gene cluster.

Martinez P , Rast JP , Arenas-Mena C , Davidson EH .

The Strongylocentrotus purpuratus genome contains a single ten-gene Hox complex >0.5 megabase in length. This complex was isolated on overlapping bacterial artificial chromosome and P1 artificial chromosome genomic recombinants by using probes for individual genes and by genomic walking. Echinoderm Hox genes of Paralog Groups (PG) 1 and 2 are reported. The cluster includes genes representing all paralog groups of vertebrate Hox clusters, except that there is a single gene of the PG4-5 types and only three genes of the PG9-12 types. The echinoderm Hox gene cluster is essentially similar to those of the bilaterally organized chordates, despite the radically altered pentameral body plans of these animals.

PubMed ID: 9990047
PMC ID: PMC15486
Article link: Proc Natl Acad Sci U S A
Grant support: [+]

References [+] :
Acampora D, The human HOX gene family. 1989, Pubmed